Nolvadex (Tamoxifen Citrate)

Nolvadex is the brand name for a drug called Tamoxifen Citrate. Tamoxifen Citrate is in a group of drugs called non-steroidal Selective Estrogen receptor modulators, or SERMs. SERMs are from a broad-class of drugs known as anti-estrogens. This means that Nolvadex has both mixed agonistic as well as antagonistic properties in relation to the Estrogen that occurs in different areas of the body.

Nolvadex is most frequently used in the treatment of patients with Breast Cancer. However, there are also clinically proven uses for Tamoxifen Citrate for sufferers of premature puberty in McCune-Albright Syndrome, infertility, Gynecomastia, Bipolar Disorder, Angiogenesis, and Riedel’s thyroiditis.

Tamoxifen Citrate has proven particularly effective in women that have metastatic breast cancer, or breast cancer that has spread from the breast to other organs or parts of the body. It is also used to treat patients after they have completed cancer surgery and/or radiation treatments to continue and help enhance the recovery process.

nolvadex pillsNolvadex has been proven to show moderate effectiveness as a preventative measure in breast cancer by reducing the instances and/or occurrences of breast cancer in patients deemed to be of a higher risk of being diagnosed with the disease.

An example of someone at a higher risk of being diagnosed with breast cancer would be a person with a long and/or higher rate of family history or genetic tendency to have breast cancer.

How Does It Work In Breast Cancer Patients?

Nolvadex is taken orally in a pill form. It has proven very effective on breast tissue. It works as it binds itself to the estrogen receptors of the breast cancer cells, which are estrogen-dependent for growth and survival. They are in essence actively blocking the cell’s ability to absorb, or take on, the estrogen. This prevents any estrogen signals from being picked up in the patient’s DNA, thus suppressing the DNA synthesis of the cancer cells.

This also blocks any form of multiplication of the cancer cells. Without the estrogen feeding the cancer cell’s growth they will die. This demonstrates the Estrogen antagonistic effects of Tamoxifen Citrate on the body.

The estrogen agonist effects can enhance the effects of Estrogen in other areas of the body to produce some positive effects on the body. For instance in the liver the effects are very positive and can result in a more desirable cholesterol profile for the patient.

Nolvadex can reduce the risk of the recurrence and/or spreading of estrogen receptor- positive breast cancer. In fact because of the success of Tamoxifen Citrate, in 1998, it became the first drug approved by the United States Food and Drug Administration, FDA, for use as a breast cancer preventative. The FDA testing at the time showed a 50% reduction in the chances of developing breast for women that were in the higher risk category for contracting the disease.

Nolvadex Side Effects

As with many, if not most, pharmaceuticals available today, Tamoxifen Citrate has some side effects that users should be made aware of.

Generally speaking, hot flashes, nausea, and vomiting have been the most common and are often confronted by up to 25% of female Nolvadex users.

However, there are some other frequent side effects to be aware of are:

  • Endometriosis: a disorder in which tissue that normally lines the uterus grows on the outside of the uterus.
  • Vaginal bleeding: any bleeding through the vagina that is not associated with a woman’s monthly cycle.
  • Vaginal discharge: bodily fluids that may be discharged through the vagina with varying colors and/or odors that are considered individually abnormal.
  • Amenorrhea or the absence of menstruation in women that would normally have regular monthly period.
  • Musculoskeletal issues that include pain and/or bone pain or bone “flare”.
  • Severe Hypercalcemia: a condition in which the calcium level in the blood is above normal.
  • Pancytopenia: is a medical condition where there is a reduction in the number of red and white blood cells, as well as platelets.
  • Stroke: a medical condition where poor blood flow to the brain results in cell death.
  • Pulmonary Embolism: the blockage of the main artery of the lung.
  • Cough
  • Increase or renewed aggravation of Asthma and Asthma symptoms.
  • Depression
  • Delusional Syndromes
  • Purpuric Vasculitis: red or purple skin discolorations that are caused by bleeding under the skin.
  • Anorexia: poor appetite caused from the treatment

Uses for Nolvadex

Nolvadex has found a popular alternative market outside of the cancer drug it is so respected for. That same reliability has made the use of Tamoxifen Citrate popular in the fitness and bodybuilding facilities as well.

It is considered very safe to use because as an Estrogen and receptor bond blocking attribute, it does not reduce the body’s Estrogen levels, but hampers the process. This blocking results in muscle growth, which is very important to bodybuilders. These individuals generally use it during their steroid cycle phase of the fitness regimen.

As with any and all pharmaceuticals, please consult a physician and/or a pharmacist before beginning a medicinal treatment program.